MTOR and neoplasm: In conclusion, in this study we: i) identified a set of miRNAs associated with mTOR expression and tumor characteristics in lung carcinoids; ii) demonstrated that miR-100 actively participates to the regulation of mTOR expression in lung carcinoid cells, and that its modulation influences responsiveness to mTOR inhibitors thus representing a novel target to sensitize lung carcinoid cells to this therapeutic strategy.