This study also identified immune disease-related genes associated with somatic mutations such as MYD88 and BCL10 in NF-κB signaling, CD79B, PAX5, and BCR in B-cell development, and MYH11, RUNX1, and TET2 in leukemia (Figure 3, Supplementary Figure 7). The gene discussed is RUNX1; the disease is immune system disorder.