B2M and primary central nervous system lymphoma: Besides, the genome-wide analysis has reported that several genes recurrently affected in PCNSL are common with systemic DLBCL, including loss of TNFAIP3, PRDM1, GNA13, TMEM30A, TBL1XR1, B2M, CD58, activating mutations of CD79B, CARD11, and translocations IgH-BCL6 [37].