Besides, the genome-wide analysis has reported that several genes recurrently affected in PCNSL are common with systemic DLBCL, including loss of TNFAIP3, PRDM1, GNA13, TMEM30A, TBL1XR1, B2M, CD58, activating mutations of CD79B, CARD11, and translocations IgH-BCL6 [37]. Here, PRDM1 is linked to primary central nervous system lymphoma.