TENM4 and primary central nervous system lymphoma: In contrast, a median of 22.2% of SNVs overlapped with the RGYW motif targeted by somatic hypermutation, and a median of 7.9% affected its hotspot position, which is considered a significant somatic hypermutation within PCNSL pathogenesis, in addition to minor gene alterations in CSMD2/3, ODZ4, and PTPRD [21].