Combined with the both data from Kaplan-Meier analysis and domain mapping of somatic mutations, the mutations in the four genes including AR, EPHA3, KMT2A, and MYH11 with significant hazard ratios for prognosis and domain mutations could be considered as candidates for genomic diagnosis and prognosis markers in PCNSL in the study. This evidence concerns the gene KMT2A and primary central nervous system lymphoma.