These results indicate that the 12 candidates are associated with SNVs/INDELs and prognoses, and 6 candidates, AR, EPHA3, KMT2A, MYH11, NTRK1, and RUNX1, harbor significant mutations in the functional domains of the proteins, which may be useful for genome diagnostics and prognostic predictions in PCNSL. This evidence concerns the gene KMT2A and primary central nervous system lymphoma.