Besides, the genome-wide analysis has reported that several genes recurrently affected in PCNSL are common with systemic DLBCL, including loss of TNFAIP3, PRDM1, GNA13, TMEM30A, TBL1XR1, B2M, CD58, activating mutations of CD79B, CARD11, and translocations IgH-BCL6 [37]. The gene discussed is CARD11; the disease is primary central nervous system lymphoma.