These results indicate that the 12 candidates are associated with SNVs/INDELs and prognoses, and 6 candidates, AR, EPHA3, KMT2A, MYH11, NTRK1, and RUNX1, harbor significant mutations in the functional domains of the proteins, which may be useful for genome diagnostics and prognostic predictions in PCNSL. The gene discussed is RUNX1; the disease is primary central nervous system lymphoma.