These results suggest that the above-mentioned genes harboring somatic hypermutations including MYD88, CD79B, MYH11, PIM1, and ERBB3 are not directly involved in the cell cycle, but rather in immune disease signaling pathways and phosphorylation of proteins such as RTKs, non-RTKs, and Ser/Thr-kinases. This evidence concerns the gene MYD88 and immune system disorder.