Several genes showed medium mutation prevalence, including ABCA13, ABCC10, CEP192, DCHS2, DNAH5, DYNC1H1, PTPRT, MYO16, LRRK2, DYNC2H1, FBN1, FCGBP, FLG, FREM2, PAPPA2, RP1L1, TTN, ZFHX4 and ZNF717. Their possible roles in CRC may be by interacting with canonical CRC genes in a network fashion as illustrated in Figure 3B. The gene discussed is FREM2; the disease is colorectal carcinoma.