IGHE and asthma: In the present study, significantly higher numbers of skin test positive patients along with concordant higher level of total serum IgE were found among child and adolescents than in adults and this was preliminarily, in accordance, to the idea20 of decline of asthma incidence and severity with age (Cut off values for normal IgE leveling blood: 4–10 years, <250IU/ml; 10–16 years, <200IU/ml;adults, <100IU/ml21).