HIF1A and cancer: A number of oncogenes, such as MYC, hypoxia inducible factors-1 alpha subunit (HIF1A), and tumor suppressor p53 (Yeung et al., 2008) as well as some pathways, such as phosphoinositide 3-kinase (PI3K/AKT) and protein kinase B (PKB), or the mammalian target of rapamycin (MTORC1) one (Wieman et al., 2007), are known to be involved in the energy metabolism regulation of cancer cells.