Our results are consistent with previous studies in PD models, Ndfip1 is decreased in 6-OHDA-treated rats and MES23.5 cells, whereas Ndfip1 overexpression leads to a decrease in DMT1 level in vitro (Howitt et al., 2014; Jia et al., 2015; Liu et al., 2015; Xing et al., 2016). Here, NDFIP1 is linked to Parkinson disease.