We have reported that DMT1 is colocalized with Aβ in senile plaques of postmortem human AD brain, and the protein levels of DMT1 are significantly elevated in the brain of β-amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice compared with wild type (WT) mice (Zheng et al., 2009). The gene discussed is APP; the disease is Alzheimer disease.