p25/Cdk5 plays roles in tauopathy, as a recent study showed that blocking p25 generation by replacing endogenous p35 with the non-cleavable mutant p35 (Deltap35) reduced phosphorylation of tau and its seeding activity in the brain of mice overexpressing mutant human tau (P301S) and thus attenuated synaptic loss and LTP impairment at hippocampal CA3 region of those mice (Seo et al., 2017). Here, MAPT is linked to tauopathy.