In studies, VEGF has been shown to contribute to the development of vestibular schwannoma and otitis media with effusion, and the use of a VEGF antagonist can alleviate hearing loss in these two diseases (Lim and Birck, 1971; Koutsimpelas et al., 2007; Plotkin et al., 2009; Cheeseman et al., 2011). This evidence concerns the gene VEGFA and otitis media with effusion.