Sinha et al. (1993) found that SPs and NFTs were extensively distributed throughout not only the ventral nucleus of the medial geniculate body but also the central nucleus of the inferior colliculus in AD patients at autopsy. Similarly, Rüb et al. (2016) found conspicuous AD-related cytoskeletal pathology in the inferior colliculus, superior olive and dorsal cochlear nucleus. Parvizi et al. (2001) also found β-amyloid and hyperphosphorylated epitopes of the tau protein in the inferior and superior colliculus and autonomic, monoaminergic, cholinergic, and classical reticular nucleus. This evidence concerns the gene MAPT and Alzheimer disease.