CAMKK2 and Alzheimer disease: Although there is currently no evidence showing that LKB1 and CaMKKβ change in the ear or brain due to aging, the environment, diet or other factors, we speculate that if expression of LKB1 and CaMKKβ is altered by the above factors, they would not only cause hearing loss but also affect downstream phosphorylation of AMPK, leading to AD.