NEDD4 and breast cancer: WBP2, a binding partner of WW domain proteins, mediates the signalling pathway of intracellular downstream molecules that possess the WW domain or SH3 domain, including WWOX,23 Nedd4,30 Rsp5p31 and TAZ.20 In mammals, WBP2 interacts biochemically with Pax8 and is required for morphogenesis of the thyroid gland.32 Emerging research indicates that WBP2 acts as an oncogene in glioma by affecting cancer cell metabolism.33 In fact, most studies about WBP2 are mainly focused on its role in breast cancer.