WBP2 and alcohol dependence: We found that WBP2 upregulation induced several signalling pathway changes in MCF-7 cells, such as systemic lupus erythematosus, alcoholism, viral carcinogenesis, necroptosis and tight junction (Top5) (Table S1), implying that as a co-activator, WBP2 overexpression could induce genome-wide changes and affect several signalling transduction in breast cancer cells.