ESR1 and breast cancer: Upregulation of WBP2 expression or its tyrosine phosphorylation level in breast cancer cells promotes tumour cell growth and metastasis via modulating ER,22 Hippo34 and Wnt signalling networks.24 Based on the correlation between WBP2 expression and breast cancer, we performed genome-wide mRNA screen using WBP2 stable expressed MCF-7 cells.