Unanswered questions for future research on the metabolism of alliinase-inhibited garlic include (a) identity of the metabolic pathways from alliin and SAC to AMS when alliinase is inactive and (b) the mechanism by which the metabolism of alliin, and especially SAC, to AMS is enhanced when alliinase is inactive. Here, ADCY10 is linked to ablepharon macrostomia syndrome.