VASH1 and diabetes mellitus: Intravenous administration of a VASH1-expressing adenoviral vector ameliorated albuminuria and glomerular alterations in type 1 (streptozotocin-induced) and type 2 (db/db) diabetic mice through not only inhibition of diabetes-induced VEGFR2 activation, but also reduced mesangial matrix production and podocyte protection [109,110].