Since inducible overexpression of soluble Flt-1 in podocytes or intramuscular transfection of a soluble Flt-1- expressing plasmid prevented albuminuria and glomerular alterations in a type 1 diabetic mouse model [14,15], soluble Flt-1 expression may increase to attenuate hyperglycemia-induced activation of VEGF-A signaling in diabetic patients. Here, VEGFA is linked to Hyperglycemia.