The first reports of PEDF in a rat model of type 1 diabetic nephropathy showed that PEDF expression was decreased in kidneys, especially in glomeruli, of the diabetic animals [50], and adenoviral overexpression of PEDF prevented diabetes-induced renal extracellular matrix production with lower expression of fibrogenic factor TGF-β [51], indicating its antifibrotic effect in diabetic nephropathy. Here, SERPINF1 is linked to diabetes mellitus.