BRCA2 and Friedreich ataxia: Components of the Fanconi anemia (FA) and HR pathways, including RAD51 (FANCR), FANCD2, BRCA1 (FANCS), and BRCA2 (FANCD1), play a vital role in protecting nascent DNA at reversed replication forks (Schlacher et al., 2011, Schlacher et al., 2012, Somyajit et al., 2015, Ying et al., 2012, Zadorozhny et al., 2017).