Components of the Fanconi anemia (FA) and HR pathways, including RAD51 (FANCR), FANCD2, BRCA1 (FANCS), and BRCA2 (FANCD1), play a vital role in protecting nascent DNA at reversed replication forks (Schlacher et al., 2011, Schlacher et al., 2012, Somyajit et al., 2015, Ying et al., 2012, Zadorozhny et al., 2017). The gene discussed is BRCA1; the disease is Friedreich ataxia.