ZMPSTE24 and Hutchinson-Gilford progeria syndrome: Fibroblasts from HGPS patients and mouse embryonic fibroblasts (MEFs) derived from progeroid models, such as Zmpste24 knock out mice, are extremely sensitive to genotoxic agents as camptothecin and etoposide, which are DSBs inducers, but also to UV irradiation that typically activates the Nucleotide Excision Repair (NER) pathway [30].