Ligand-induced EGFR signaling stimulates cell proliferation, differentiation, and survival and it plays an important, yet complex role in the development and progression of CRC – e.g. deletion of EGFR from myeloid cells, but not intestinal epithelial cells protects mice from inflammation-induced intestinal cancer and ApcMin-dependent intestinal tumorigenesis [5]. The gene discussed is EGFR; the disease is colorectal carcinoma.