ACE and hydrops fetalis: We further tested whether the approved treatment of HF such as angiotensin inhibitors (ACE-Is) is also found to be effective in the present cohort of the HF patients, and we found that ACE-Is seem to be effective in the prevention of cardiovascular events despite statistically insignificant levels of p = 0.08 (Fig. 2), indicating that the conventional and approved treatment strategies of HF patients seem to be effective in the present cohort.