Sub-group analysis revealed thatAC genotype and carriers of C were associated with asthenozoospermia.Also, the C allele was significantly associatedwith oligozoospermia and non-obstructive azoospermia.Therefore, IL-1α C376A is a potential geneticrisk factor for male infertility, although further studiesof different ethnicities in Iran and other populations arerequired to obtain a more accurate picture. The gene discussed is IL1A; the disease is male infertility.