MAPT and Alzheimer disease: In addition to their correlations with R2 values in extensive brain areas, both coexpression module m109 (transcriptional regulation) and comethylation module m66 (synapses and morphogenesis) have significant correlations with a wide range of AD clinical and pathologic phenotypes, including β-amyloid load and tau tangle density, and with AD diagnosis, global cognition and cognitive systems (Fig. 5).