In case of the cancer cells, Vinik et al. recently concluded that “the evidence, gathered thus far, implicates Gal-8 as a driver of a ‘vicious cycle’, whereby cancer cells that overexpress and secrete Gal-8 benefit from its potential to promote their own growth; potentiate epithelial–mesenchymal transition and induce secretion of metastasis-promoting agents at the metastatic niche that induce further recruitment and seeding of cancer cells. Here, LGALS8 is linked to cancer.