Phosphatase and tensin homolog (PTEN) is an important tumor suppressor with both lipid phosphatase and protein phosphatase activities.27–29 One of the canonical functions of PTEN is to inhibit the phosphatidylinositol 3-kinase (PI3K)–AKT pathway through its lipid phosphatase activity30,31 — PTEN dephosphorylates phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3) to form phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), inhibiting AKT and its downstream signaling pathways. Here, AKT1 is linked to neoplasm.