Looking at the patient-specific response to combinatorial drug treatments in more detail (Fig. 6c, d) we observed that the top hit is different for each patient (PHT-427 and Oxaliplatin for primary tumour #1, TNFa and Oxaliplatin for primary tumour #2, GDC0941 and MK-2206 for the intraepithelial neoplasia and AZD6244 and PHT-427 for liver metastasis). Here, TNF is linked to intraepithelial neoplasia.