Specifically, we included two drugs that are currently used in clinical chemotherapy as first line treatment for pancreatic cancer (Gemcitabine and Oxaliplatin), seven drugs that have specific kinase targets which play key roles in different pathways (i.e., IKK, MEK, JAK, PI3K, EGFR, AKT and PDPK1 inhibitors) and one cytokine (TNFα) that activates the extrinsic apoptosis pathway. This evidence concerns the gene PDPK1 and familial pancreatic carcinoma.