Similarly, percentage of tumor cells with anti-PCNA staining positively in nuclear from the E2-treated group was significantly higher than that from the control and E2/RS102895 group, and this percentage of E2/RS102895-treated tumors was also higher than that of RS102895 group (P < 0.001 and P < 0.05 separately, Fig. 7e). The gene discussed is PCNA; the disease is neoplasm.