At baseline in this study, all HISs were cART-naïve with detectable plasma viral loads (median 4.68lg10 copies/ml, IQR 4.18–5.12lg10 copies/ml), and most patients exhibited moderate immunodeficiency (median CD4+ T cell count: 331 cells/mm3, IQR: 247–429 cells/mm3). This evidence concerns the gene CD4 and immune system disorder.