Interestingly, RNF20 depletion has been shown to enhance NF-κB-dependent gene transcription, and TNF-mediated H2Bub1 down-regulation augments NF-κB’s response in the up-regulation of proinflammatory cytokines or chemokines that may act in an autocrine or paracrine fashion to sustain the prosurvival gene expression in cancer cells. This evidence concerns the gene TNF and cancer.