Interestingly, RNF20 depletion has been shown to enhance NF-κB-dependent gene transcription, and TNF-mediated H2Bub1 down-regulation augments NF-κB’s response in the up-regulation of proinflammatory cytokines or chemokines that may act in an autocrine or paracrine fashion to sustain the prosurvival gene expression in cancer cells. The gene discussed is RNF20; the disease is cancer.