Pathologically, this intrinsically aggressive cancer is characterized by: (1) high intra-tumoral lymphocyte infiltrations; (2) the presence of EBV genome and expression of EBV latent genes including EBERs, EBNA1, LMP1, LMP2 and BARTs; (3) high levels of circulating EBV DNA in the plasma of NPC patients [14,15]. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.