Yet, based on the published WES data of 36 HPV(+) HNSCC tumors from the TCGA, HPV(+) HNSCC were found to have almost no (or <1%) somatic TP53 mutation, while HPV(−) HNSCC were characterized by a very high rate of TP53 mutations (~85%; 206/243 cases). Here, TP53 is linked to head and neck squamous cell carcinoma.