As shown in Figure 1, apart from NF-κB aberrations (34.2% cases) that was published to be the most frequently altered pathway, PI3K pathway mutations rank the second most commonly mutated signaling pathway in EBV(+) NPC (20.7% cases), followed by the MAPK pathway (11.7% cases), and JAK/STAT, NOTCH, WNT (all with 10.8% cases mutated). This evidence concerns the gene PIK3CA and nasopharyngeal carcinoma.