In our study, we demonstrated that decreased expression of PERK and IRE-1α in SH-EAE-treated NSCLC cells is accompanied by the reduction of angiogenesis, which is evidenced by a decreased expression of VEGF (Figure 6) and decreased development of intersegmental vessels (ISVs) in zebrafish larvae (Figure 9). Here, VEGFA is linked to non-small cell lung carcinoma.