In the present study, we found that ethyl acetate extract of Scindapsus cf. hederaceus, named as SH-EAE, has a great potential of targeting UPR-related proteins in NSCLC cells as evidenced by a substantial decrease in protein expression of ER stress sensors, including IRE-1α and PERK (Figure 2A). This evidence concerns the gene EIF2AK3 and non-small cell lung carcinoma.