APP and neuroblastoma: A study conducted by Shi et al., utilizing an in vitro mouse neuroblastoma N2a cell line [stably expressing wild-type presenilin 1 (PS1wt) and Swedish mutant APP (APPsw), showed that LPA increases the production of Aβ by upregulating the expression of β-secretase (BACE1) without altering the expression of APP or γ-secretase complex proteins [144].