In our study, the increase in cold pain threshold in hands and the normalization of cold detection threshold in MS patients after therapy could reflect a cannabinoid-mediated modulation on either TRPA1 or TRPM8 channels, probably via activation (and consequent desensitization) of TRPA1 and inhibition of TRPM8, although the mechanisms of action of the single channels need to be elucidated [40]. Here, TRPM8 is linked to myeloid sarcoma.