At first glance, it is not surprising that the WT immunogen stimulated a larger number of IGH and IGK/IGL lineages, as it expresses more epitopes than the NLGS-3 Core; especially the variable V1, V2 and V3 domains which are known to be immunogenic, both in the context of HIV-1 infection and immunization with Env [39, 40, 49–55]. This evidence concerns the gene ERVW-1 and HIV-1 infection.