These studies, together with others showing that hyaluronan and TSG-6 affect immune cell accumulation during lung inflammation [6, 14, 25, 41, 44, 64, [67], [68], [69], [70]], suggest that specific manipulation of hyaluronan or TSG-6 may provide a novel method to improve lung function in a wide variety of respiratory disorders. Here, TNFAIP6 is linked to respiratory system disorder.