TGFB1 and hereditary hemorrhagic telangiectasia: We investigated whether the four TGFβ modifier locus variants previously reported in HHT lung AVM and seven variants from sporadic AVM studies are associated with organ VM and with brain VM ICH in a large cohort of Caucasian HHT patients enrolled by the Brain Vascular Malformation Consortium (BVMC) (Akers et al., 2013).