Our study conducted in parallel with the present study showed that treatment with empagliflozin improved the survival rate of OLETF during a period of 48 h after MI from 40% to 70%, and the protection was associated with increased ketone utilization in energy metabolism, preserved ATP level and restoration of SOD2 and catalase levels in the myocardium at 12 h after MI (Oshima et al. The gene discussed is SOD2; the disease is myocardial infarction.