2017) and to reduce liver TG level in diabetic mice (Suzuki et al. 2014). In contrast, we found that empagliflozin increased lipid droplets and TG level in the myocardium (Fig. 8). Administration of an SGLT2 inhibitor has been reported to increase the plasma level of free fatty acid (FFA) in patients with type 2 diabetes (Ferrannini et al. 2014) and in a high fat‐fed rat model (Yokono et al. 2014) due to enhanced lipolysis. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.