TP53 and nasopharyngeal carcinoma: Moreover, Nutlin-3 can activate the p53 pathway and sensitize EBV-positive nasopharyngeal carcinoma cells to cisplatin-induced apoptosis [97] The use of Nutlin-3 in Burkitt lymphoma cells chronically infected with EBV has been shown to disrupt the interaction of p53 with MDM2 and to facilitate apoptosis [98].