The impairment of oncosuppressors by viral factors was first identified by the study of large and small T antigens encoded by the simian vacuolating virus 40 (SV40) demonstrating their ability to inhibit the activity of tumor suppressors such as p53, pRb, p107, and p130/Rb and to cause evasion of apoptosis [5]. This evidence concerns the gene TP53 and neoplasm.