A number of proteins encoded by conserved or unique genes have been suggested to be responsible for KS pathogenesis: K1, K2, vMIPS, K4, K4.1, K5, K9, K12, ORF-6, ORF-71, ORF-72, ORF-73, ORF-74, and K15 [78]. The gene discussed is ATP6AP1; the disease is Kaposi's sarcoma.