The assessment of RANK mRNA levels found a preferential association with high tumor size and grade, and with negative estrogen receptors in one study [13], but another study using RT-PCR found that the RANK transcript levels were lower in tumors than in normal tissue samples, and reduced expression of RANK was associated with general and bone metastases or death because of the disease [14]. Here, TNFRSF11A is linked to neoplasm.