Therefore, due to the different pathological effects of ANGPTL2 in the accumulation of inflammatory factors and induction of insulin resistance, it is also necessary to study this factor in obese PCOS women, but since obestatin, in our study and previous studies, showed significant correlations with the factors involved in the pathogenesis of PCOS, more studies are needed to clarify the pathological mechanisms associated with PCOS. This evidence concerns the gene ANGPTL2 and Insulin resistance.