INS and polycystic ovary syndrome: In our study, there was no significant difference in the serum levels of obestatin in PCOS women compared to the control group, and on the other hand, a significant negative correlation was observed between obestatin and insulin, HOMA-IR, so that in the study of Abd El-Fattah AI and his colleagues serum levels of obestatin showed a significant decrease in Egyptian obese PCOS patients compared to non-obese PCOS patient and control group.