Previous studies showed that the concentration of ANGPTL2 is regulated by the levels of obesity, so that levels of this factor decreased with weight loss and are significantly correlated with systemic insulin resistance and inflammation [11,33], also in a study conducted by Oike Y and his colleagues reported that the circulation levels of ANGPTL2 decreases in parallel with the reduction of adipose tissue in obese diabetic patients treated with pioglitazone, a drug that reduces adipose tissue and suppresses inflammation and increases insulin sensitivity [34]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.