A significant positive correlation was observed between ANGPTL2 and insulin (p = 0.02), HOMA-IR (p = 0.01) and on the other hand a significant negative correlation was observed between obestatin and insulin (p = 0.01), HOMA-IR (p = 0.008) in PCOS group (Table 3) and this correlation in control group was also observed but no significant correlation was observed between ANGPTL2 and obestatin with BMI in PCOS and control group. This evidence concerns the gene INS and polycystic ovary syndrome.