ANGPTL2 and obesity due to melanocortin 4 receptor deficiency: Studies show that circulating levels of ANGPTL2 in humans and mice are both dependent on insulin resistance, adiposity and inflammation and for this reason, ANGPTL2 is known as an inflammatory mediator derived from adipose tissue that links obesity to systemic insulin resistance [8,9,10], so that the removal of ANGPTL2 in obese mice resulted in a reduction in adipose tissue inflammation and systemic insulin resistance [8].