Ezh2 peaks in Cluster 1 and 2 also overlapped with promoters and H3K27me3 in human NPCs, consistent with the idea that these Ezh2 and H3K27me3 peaks likely represent Ezh2 peaks commonly found in tumor-initiating cells before the introduction of H3.3K27M mutation. The gene discussed is EZH2; the disease is neoplasm.