Together, these results show that forced increase in H3K27ac at the WT1 promoter in SF8628 cells leads to reduced H3K27me3, increased expression of WT1 and decreased proliferation of DIPG cells, supporting the idea that H3K27me3-mediated silencing of WT1 supports the proliferation of DIPG cells. Here, WT1 is linked to diffuse intrinsic pontine glioma.