In this first study of CT with PEG‐IFNα2 and ruxolitinib in patients with PV (n = 32) or low‐/intermediate‐risk MF (n = 18) ‐ mainly patients being intolerant and/or refractory to IFNα2 monotherapy (94%) ‐ remission (ELN and IWG‐MRT 2013 revised response criteria including histologic, hematologic, and clinical responses26, 27) was achieved at 12 months of follow‐up in a subset of PV patients (9%, PR) and a large fraction of MF patients (39%, including CR in 17%) in concert with a significant decline in the median %V617F. This evidence concerns the gene IFNA2 and acquired polycythemia vera.