In conclusion, the preliminary results from this study suggest that CT with low‐dose PEG‐IFNα2 and ruxolitinib is feasible and efficacious in patients with low‐/intermediate‐risk MF and, to a lesser extent, in patients with PV, including in patients who were unresponsive or intolerant to IFNα2 monotherapy. Here, IFNA2 is linked to acquired polycythemia vera.