Overexpression of protein tyrosine kinases (PTKs), such as EGFR, HER2, and IGFR activate different cell signaling pathways that include PI3/AKT, NIFκB, STAT3, and ERK1/2, which also lead to aberrant expression apoptosis related proteins in cancer cells that are the major causes of cancer cells resistance to chemotherapies. This evidence concerns the gene IGF1R and cancer.