NFE2L2 and Familial prostate cancer: al. [68] analyzed the immunohistochemical results of anti-oxidant response genes on prostate cancer cells {NRF2 (nuclear factor erythroid 2–related factor 2) and NQO1(NAD(P)H Quinone Dehydrogenase 1)} and found that it was more up-regulated after hormone ablation in prostate carcinoma samples after ADT (androgen deprivation therapy) than in untreated specimens or in murine prostate glands after castration, suggesting that ADT induces cellular senescence processes accompanied by secretory phenotypes and anti-oxidant responses in prostate cancer cells.