ABCB1 and cancer: The correlation of point mutations in class III β-tubulin (TUBB3) and the prominent overexpression of ATP-binding cassette P-glycoprotein (ABCB1) have been protruding mechanisms of resistance to microtubule disruptors such as paclitaxel (PTX) for many cancers, These findings highlight the control of the TUBB3 response to ABCB1 genetic suppressors as a mechanism to reverse the profuse development of multidrug resistance in cancer.