It is also notable that UHRF1 regulates other TSG as observed with CDX2, CDKN2A, RUNX3, FOXO4, PPARG, BRCA1 and PLM in gastric cancer, SOCS3 and 3OST2 in endometrial carcinoma, RB1 in Jurkat and osteosarcoma cells, as well as BRCA1 in cancer breast cell lines. The gene discussed is BRCA1; the disease is cancer.