HHEX and neoplasm: In this pathway, the Mst1/2 (serine/threonine kinases/Hippo in Drosophila) and LATS1/2 (large tumor suppressor) together with the adaptor protein SAV1(Salvador homologue 1) and hMOB1 are the core players that transmit signals from upstream tumor suppressors molecules (Fat4, RASSF1A, Kibra, Merlin, hEx, and hWW45) to the downstream targets and tightly restrict the activities of homologous oncoproteins YAP (Yes kinase-associated protein) and (TAZ) (transcriptional co-activator with PDZ-binding motif) [50,51].