Authors investigated the impact of mix of resveratrol (which is commonly used as a stimulator of SIRT1 expression), capsaicin, piceatannol and sulphoraphane in varied combinations with analog of gemcitabine, which is used in the systemic chemotherapy, on apoptosis of pancreatic adenocarcinoma cell lines. Here, SIRT1 is linked to pancreatic adenocarcinoma.