HaploReg, a tool for visualizing 1000 Genomes Project SNP LD information in conjunction with Roadmap Epigenomics and ENCODE chromatin state and protein binding annotation, shows an association of rs11140810 with markers of H3K27 acetylation (linked to active transcription) in the brain (Table 4), as well as altered regulatory motifs including forkhead box (Foxa), glioma-associated oncogene (GLI), hypermethylated in cancer (Hic1), and zinc finger protein (Zec) [41]. This evidence concerns the gene ZNF146 and cancer.