In HPV-related cancers, the E6 and E7 viral oncoproteins are responsible for maintaining the malignant phenotype and promote a metabolic switch, together with other viral proteins, such as E5 and E2, even though E6 and E7 regulate two critical enzymes of the glycolytic pathway, hexokinase and pyruvate kinase, as well as other proteins involved in lactate production, such as lactate dehydrogenase. The gene discussed is ARHGEF15; the disease is cancer.