TGFBR1 and acute respiratory distress syndrome: Runx1 is a target for both Cdk6 and Erk1/2 [35, 54], and it seems that in inflammatory settings associated with ARDS, the TGFβ/Alk5-dependent Erk1/2 kinase activation, Cdk6 regulation and Runx1 transcriptional activity are responsible for ARDS-associated microvascular remodeling and lung tissue repair.