TBR1 and acute respiratory distress syndrome: As the EVARDSAlk5Runx1p52 show no therapeutic benefit on LPS-treated ECs and LPS-mouse model of ALI, it appears that even if the EVARDS possess the TβR1/TβRII heteromeric complexes, the lack of the Runx1p66 isoform is critical for ARDS resolution and survival.