RUNX1 and acute respiratory distress syndrome: In sum, studies to evaluate whether or not the EVARDSAlk5Runx1p66 have a broad therapeutic effect beyond the LPS injury and to validate the finding in a larger cohort of ARDS patients will help to establish the expression pattern of Runx1 isoforms not only as a reliable circulatory biomarker of ARDS activity, but also as a novel determinant of the molecular mechanism for lung tissue repair and recovery after severe injury.