By this reason, we propose that the CCTTT14/TT haplotype could be a useful marker to identify patients who will require pharmacological treatment with iNOS inhibitors and a strong early stimulation program to induce the synaptic plasticity process in the cerebral cortex in order to decrease the severity of neurological sequels following the HIE and try to avoid the development of cerebral palsy. The gene discussed is NOS2; the disease is perinatal asphyxia.