Meta-analyses have aggregated studies that differed in age at BMI assessment, attained age of participants, and degree of adjustment for potential confounding, and results were not stratified by other risk factors.2,3,4,5,15,16,17,18 Some studies suggest that the association of premenopausal adiposity with risk varies by tumor characteristics,2,7,17,18,19 but larger studies are needed to provide stable estimates by hormone receptor status or intrinsic tumor subtype. The gene discussed is NR4A1; the disease is neoplasm.