Many podocyte genes are dysregulated by HIV infection in vitro and in animal models and genes with likely roles in HIV-induced podocyte death include APOL1 (discussed below) (48–50), Fas (51), KLF6 (52), p53 (53), and p66ShcA (54), the NLRP3 inflammasome (55). The gene discussed is APOL1; the disease is HIV infectious disease.