SQSTM1 and hepatocellular carcinoma: In support of these findings, we also found that Nrf2 activation provided metabolic reprogramming of glucose and glutamine through the activation of Nrf2 in HCC harboring phosphorylated p62 (p-S349) (Figure 3B), which led to increased cell proliferation and resistance to anti-cancer agents of HCC (37) (Figure 4).