SQSTM1 and cancer: Furthermore, accumulating evidence demonstrates that the abnormal expression of p62 is associated with malignancy in various cancers, including liver (22, 37), kidney (38, 39), lung (40), breast (41, 42), pancreatic (43), prostate (44, 45), head and neck (46, 47), ovarian (48, 49), oral (50, 51), colon (52, 53), endometrial (54), skin (55, 56), and gastric cancers (57).