The degree of the loss of the favorable prognostic influence of NK-activating ligands, on OS relative to RFS, varied depending on the BC subtype: slight drop for basal-like subtype (9%), moderate drop for luminal A and HER2-positive subtypes (22.5% and 50% respectively) and dramatic drop for luminal B subtype (85.5% less NK-activating ligands associated with longer OS than with longer RFS) (Figure 2A). The gene discussed is ERBB2; the disease is breast cancer.