Analysis of the association between the prognostic role of the mRNA expression of NK receptor ligands and the different BC subtypes showed that the prognostic influence of CD27, CD48, MICB, SLAMF6, TNFSF9, ULBP1, HLA-C, NECL5, COL3A1, HLA-B, PDL1, and PDL2 is independent of the BC molecular subtype whereas the effect of the other NK receptor ligands on patient relapse and survival may vary between the different BC subtypes. This evidence concerns the gene CD48 and breast cancer.