We have previously shown that physiological concentrations of exogenous palmitate as a model for dietary saturated fat intake induce a partial ER-stress response and CHOP-dependent apoptosis in HER2/neu-positive breast cancer cells, which is accompanied by a significant reduction in HER2 and HER3 protein levels and sensitizes cells to trastuzumab treatment [14]. The gene discussed is DDIT3; the disease is breast cancer.