The underlying cause of this lipotoxicity is most likely due to a combination of genetic alterations that exist in HER2/neu-positive breast cancer cells, considering that the HER2 amplicon has been shown to comprise several genes in a large section on chromosome 17 [3, 4, 15–19] and other genes have been shown to be co-overexpressed and required for breast cancer cell survival [6]. Here, ERBB2 is linked to breast cancer.