Alternatively, Chio et al. recently showed that Nrf2 regulates the activity of the translational machinery, with genetic disruption of Nrf2 in pancreatic cancer organoids causing defects in epidermal growth factor receptor signalling upstream of cap-dependent translation, as well as oxidation of specific translational regulatory proteins [35]. The gene discussed is NFE2L2; the disease is familial pancreatic carcinoma.