CEACAM5 and cholestasis: Moreover, when compared to classical tumour markers for CRC in this context, circulating levels of suPAR showed an only slightly lower diagnostic power than CEA (AUC 0.910) or CA19-9 (AUC 0.858) but was higher than standard markers of liver damage or cholestasis such as ALT (AUC 0.592) or ALP (AUC 0.790) (Figure 2B).