To further explore these results on a potential prognostic role of suPAR serum levels, we next performed extensive uni- and multivariate Cox-regression analysis including various laboratory parameters such as tumor markers (CEA and CA19-9), markers of liver and kidney function (AST and creatinine), inflammatory parameters (leucocyte count and CRP) as well as clinical and pathological parameters (BMI, largest diameter of CRLM, location of primary CRC). This evidence concerns the gene CEACAM5 and neoplasm.