AFP and neoplasm: Univariate analysis (Table 3) identified the following factors as significantly associated with disease recurrence: post-operative AFP level (HR 1.112, 95% CI: 1.02–1.21, P = 0.012), tumor size (HR 1.061, 95% CI: 1.01–1.11, P = 0.013), multiple tumors (HR 1.881, 95% CI: 1.23–2.86, P = 0.003), microvascular invasion (HR 1.645, 95% CI: 1.02–2.63, P = 0.037), stage II or higher (HR 1.553, 95% CI 1.04–2.31, P = 0.031), and no antiviral treatment (HR 1.519, 95% CI: 1.01–2.28, P = 0.045).